OcellO announces two year agreement with Merus to provide in vitro research services for MCLA-158 and other undisclosed Biclonics ® programs

LEIDEN, the Netherlands, March. 28, 2019 OcellO B.V., a Contract Research Organisation offering 3D cell based assay services for drug discovery to the pharmaceutical industry, today announced that it entered an agreement to provide in vitro research services to Merus N.V. (Nasdaq:MRUS), a clinical-stage immuno-oncology company developing innovative bispecific antibody therapeutics, for Merus’ MCLA-158 Biclonics® program and other undisclosed Biclonics® discovery programs.

Pursuant to the agreement, OcellO will provide €1 million of in vitro research services to Merus over a period of two years. OcellO will also utilize its 3D immune-oncology co-culture screening technology to support other undisclosed Merus Biclonics® discovery programs.

Merus is developing MCLA-158 in Phase 1 in patients with solid tumors with an initial focus on metastatic colorectal cancer. MCLA-158 is designed to bind to cancer stem cells expressing leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) and epidermal growth factor receptors (EGFR). “With this new commitment Merus looks forward to extending its long-standing productive relationship with the OcellO team” said Mark Throsby, CSO of Merus.

“This significant service agreement between OcellO and Merus enables OcellO to further invest in its technology platform – particularly for immune-oncology drug discovery – to meet the needs of Merus and other companies in the immune-oncology space” said Leo Price, CEO of OcellO.

About OcellO B.V.

OcellO is a leading provider of compound testing services using advanced organotypic human tissue models of cancer, inflammation and polycystic kidney disease. Automated 3D cell culture is combined with high content 3D imaging and analysis in a robust platform that provides scalability without compromising biological complexity. Cancer drug discovery services utilise organoids, PDX- derived tumouroids and patient tumour-derived models representing most solid tumour types and incorporating different components of the immune system. OcellO’s technology is leveraged by an engaged and expert team of scientists and project managers whose goal is to enable customers to explore and demonstrate the full potential of their lead compounds and compound collections. For more information contact:

OcellO B.V.

email: [email protected]

website: www.OcellO.nl